Piwi, Hiwi, Miwi: essential genes for effective spermiogenesis
نویسندگان
چکیده
منابع مشابه
Two mouse piwi-related genes: miwi and mili
Genes belonging to the piwi family are required for stem cell self-renewal in diverse organisms. We cloned mouse homologues of piwi by RT-PCR using degenerative primers. The deduced amino acid sequences of mouse homologues MIWI and MILI showed that each contains a well-conserved C-terminal PIWI domain and that each shares significant homology with PIWI and their human counterparts HIWI. Both mi...
متن کاملMIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis.
Noncoding small RNAs have emerged as important regulators of gene expression at both transcriptional and posttranscriptional levels. Particularly, microRNA (miRNA)-mediated translational repression involving PIWI/Argonaute family proteins has been widely recognized as a novel mechanism of gene regulation. We previously reported that MIWI, a murine PIWI family member, is required for initiating ...
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M IWI and PIWI-interacting RNA (piRNA), which binds to PIWI family members including MIWI, contribute to post-transcriptional regulation in spermiogenesis, however, their molecular functions had been unclear. Recently, Zhao and colleagues reported that loading of piRNA to MIWI leads to ubiquitin-proteasome mediated degradation in late spermatid and that this process is essential for the maturat...
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Objective: This study is to investigate whether CKLF-like MARVEL transmembrane domain-containing protein 2 (CMTM2) is involved in spermatogenesis in mice. CMTM2 is highly expressed in testis, and could possibly a potential spermagogenesis specific gene. Methods: CMTM2-deficient mouse model was generated. Northern, RT-PCR and Western blotting analysis were performed on total RNA derived from wil...
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Spermatogenesis can be divided into three stages: spermatogonial mitosis, meiosis of spermatocytes, and spermiogenesis. During spermiogenesis, spermatids undergo dramatic morphological changes including formation of a flagellum and chromosomal packaging and condensation of the nucleus into the sperm head. The genes regulating the latter processes are largely unknown. We previously discovered th...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2017
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2017.95